1.NIAID, NIH, Bldg. 33, Bethesda, MD 20892, USA.
J Leukoc Biol. 2014 Apr;95(4):551-62. doi: 10.1189/jlb.1113599. Epub 2014 Feb 14.
MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.
MHC Ⅰ类分子在细胞表面展示寡肽，使 T 细胞能够对细胞内病原体和肿瘤进行免疫监视。检测病毒的速度至关重要，因为病毒可以在短短几个小时内完成一个完整的复制周期，而肿瘤检测通常是一项大海捞针的工作。我们回顾了目前支持非随机、分隔选择肽生成底物的证据，这些底物主要集中在快速降解的翻译产物上，作为肽前体的主要来源，以优化对病原体和肿瘤的免疫监视。
