Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing 210029, PR China.
Crit Rev Oncol Hematol. 2012 Jun;82(3):249-58. doi: 10.1016/j.critrevonc.2011.08.004. Epub 2011 Oct 1.
Necrosis plays an important role in multiple physiological and pathological processes. Recently, a relatively new form of necrosis has been characterized as "necroptosis". Morphologically, necroptosis exhibits the features of necrosis; however, necroptosis exhibits a unique signaling pathway that requires the involvement of receptor interaction protein kinase 1 and 3 (RIP1 and RIP3) and can be specifically inhibited by necrostatins. Necroptosis has been found to contribute to the regulation of immune system, cancer development as well as cellular responses to multiple stresses. In this review, we will summarize the signaling pathway, biological effects and pathological significance of this specific form of programmed cell death.
细胞坏死在多种生理和病理过程中发挥着重要作用。最近，一种相对较新的细胞坏死形式被定义为“细胞坏死性凋亡”。在形态学上，细胞坏死性凋亡表现出坏死的特征；然而，细胞坏死性凋亡具有独特的信号通路，需要受体相互作用蛋白激酶 1 和 3（RIP1 和 RIP3）的参与，并且可以被特异性的坏死抑制剂所抑制。细胞坏死性凋亡被发现参与免疫系统的调节、癌症的发展以及细胞对多种应激的反应。在这篇综述中，我们将总结这种特定形式的程序性细胞死亡的信号通路、生物学效应和病理意义。
