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保守治疗非输卵管异位妊娠。

Conservative management of nontubal ectopic pregnancies.

机构信息

Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA.

出版信息

Fertil Steril. 2011 Dec;96(6):1391-1395.e1. doi: 10.1016/j.fertnstert.2011.09.021. Epub 2011 Oct 1.

Abstract

OBJECTIVE

To report successful conservative management of nontubal ectopic pregnancies.

DESIGN

Retrospective case series.

SETTING

University tertiary-care hospital.

PATIENT(S): Sixty-four women with diagnosis of nontubal ectopic pregnancies (cervical, cornual, and cesarean section scar) were treated with minimally invasive procedures.

INTERVENTION(S): Systemic methotrexate alone or combined with ultrasound-guided fetal intracardiac injection of potassium chloride.

MAIN OUTCOME MEASURE(S): Success of the treatment, preservation of the uterus, rate of serious complications, and the need for additional interventions.

RESULT(S): Conservative treatment was successful in 63 patients with nontubal ectopic pregnancies. One patient had rupture of cornual pregnancy and underwent cornual resection. None of the patients in this case series required hysterectomy. This series included four patients with heterotopic pregnancies, three of whom continued intrauterine pregnancy to term gestation after conservative treatment. Seven patients experienced minimal morbidity that was treated with additional nonsurgical interventions.

CONCLUSION(S): Conservative management and fertility preservation is feasible in most nontubal ectopic pregnancies.

摘要

目的

报道非输卵管妊娠的成功保守治疗。

设计

回顾性病例系列研究。

地点

大学三级保健医院。

患者

64 名被诊断为非输卵管妊娠(宫颈、宫角和剖宫产瘢痕部位)的女性接受了微创治疗。

干预措施

单独使用甲氨蝶呤或联合超声引导下胎儿心内氯化钾注射。

主要观察指标

治疗的成功率、子宫的保留率、严重并发症的发生率以及是否需要额外的干预措施。

结果

63 例非输卵管妊娠患者的保守治疗获得成功。1 例患者发生宫角妊娠破裂,行宫角切除术。本病例系列中无患者需要行子宫切除术。该系列包括 4 例异位妊娠患者,其中 3 例在保守治疗后继续宫内妊娠至足月。7 例患者出现轻微并发症,经额外的非手术干预治疗后得到缓解。

结论

在大多数非输卵管妊娠中,保守治疗和生育力保存是可行的。

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