解析素在炎症和疼痛缓解中的新作用。
Emerging roles of resolvins in the resolution of inflammation and pain.
机构信息
Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
出版信息
Trends Neurosci. 2011 Nov;34(11):599-609. doi: 10.1016/j.tins.2011.08.005. Epub 2011 Sep 30.
Abstract
Resolvins, including D and E series resolvins, are endogenous lipid mediators generated during the resolution phase of acute inflammation from the omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Resolvins have potent anti-inflammatory and pro-resolution actions in several animal models of inflammation. Recent findings also demonstrate that resolvin E1 and resolvin D1 can each potently dampen inflammatory and postoperative pain. This review focuses on the mechanisms by which resolvins act on their receptors in immune cells and neurons to normalize exaggerated pain via regulation of inflammatory mediators, transient receptor potential (TRP) ion channels, and spinal cord synaptic transmission. Resolvins may offer novel therapeutic approaches for preventing and treating pain conditions associated with inflammation.
摘要
解析素，包括 D 系列和 E 系列解析素，是从 ω-3 多不饱和脂肪酸二十二碳六烯酸 (DHA) 和二十碳五烯酸 (EPA) 在急性炎症的消退阶段生成的内源性脂质介质。解析素有在几种炎症动物模型中发挥强大抗炎和促消退作用。最近的研究结果还表明，解析素 E1 和解析素 D1 都可以有效地抑制炎症和术后疼痛。这篇综述主要关注解析素在免疫细胞和神经元上的受体作用机制，通过调节炎症介质、瞬时受体电位 (TRP) 离子通道和脊髓突触传递来使过度的疼痛正常化。解析素可能为预防和治疗与炎症相关的疼痛提供新的治疗方法。
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