Bannenberg Gerard L
Centro Nacional de Biotecnología/CSIC, Department of Plant Molecular Genetics, Universidad Autónoma, Cantoblanco, Madrid, Spain.
Curr Opin Drug Discov Devel. 2009 Sep;12(5):644-58.
Research on the formation of novel enzymatic oxygenation products derived from the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has revealed the endogenous formation of several novel autacoids that have been termed resolvins and protectins. The elucidation of the chemical structures of resolvins and protectins, and the assessment of their endogenous functions, are providing a new understanding of the role of endogenous omega-3 fatty acid-derived lipid mediators in tissue protection, counteraction of inflammation and the activation of inflammation resolution. This review emphasizes the structural aspects of resolvin biosynthesis and metabolic inactivation, which are of central importance for understanding the current and future development of therapeutically relevant, stable analogs that may activate inflammation resolution.
对源自ω-3脂肪酸二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的新型酶促氧化产物形成的研究揭示了几种新型自分泌物质的内源性形成，这些自分泌物质被称为消退素和保护素。消退素和保护素化学结构的阐明以及它们内源性功能的评估，正在为内源性ω-3脂肪酸衍生的脂质介质在组织保护、炎症对抗和炎症消退激活中的作用提供新的认识。本综述强调了消退素生物合成和代谢失活的结构方面，这对于理解可能激活炎症消退的治疗相关稳定类似物的当前和未来发展至关重要。
