Centre Hospitalier Emile Roux, F-43012 Le Puy en Velay, France.
Int J Pharm. 2011 Dec 12;421(1):63-71. doi: 10.1016/j.ijpharm.2011.09.023. Epub 2011 Sep 21.
The impact of 100 Hz (Hertz) acoustic frequency airflow on sinus drug deposition of aerosols was investigated using a human plastinated nasal cast. The influence of drug concentration and endonasal anatomical features on the sinus deposition enhanced by the 100 Hz acoustic airflow was also examined.
Plastinated models were anatomically, geometrically and aerodynamically validated (endoscopy, CT scans, acoustic rhinometry and rhinomanometry). Using the gentamicin as a marker, 286 experiments of aerosol deposition were performed. Changes of airborne particles metrology produced under different nebulization conditions (100 Hz acoustic airflow and gentamicin concentration) were also examined.
Aerodynamic and geometric investigations highlighted a global behaviour of plastinated models in perfect accordance with a nasal decongested healthy subject. The results of intrasinus drug deposition clearly demonstrated that the aerosols can penetrate into the maxillary sinuses. The 100 Hz acoustic airflow led to increase the deposition of drug into the maxillary sinuses by a factor 2-3 depending on the nebulization conditions. A differential intrasinus deposition of active substance depending on maxillary ostium anatomical features and drug concentration was emphasized.
The existence of a specific transport mechanism of penetration of nebulized particles delivered with acoustic airflow was proposed.
本研究旨在利用人体塑化鼻模型探讨 100 赫兹（Hz）声频气流对气溶胶鼻窦药物沉积的影响。同时，还研究了药物浓度和鼻腔内解剖特征对 100 Hz 声频气流增强鼻窦沉积的影响。
对塑化模型进行解剖学、几何学和空气动力学验证（鼻内窥镜检查、CT 扫描、声鼻测量和鼻阻力测量）。使用庆大霉素作为示踪剂，进行了 286 次气溶胶沉积实验。还检查了在不同雾化条件（100 Hz 声频气流和庆大霉素浓度）下产生的气载颗粒计量学变化。
空气动力学和几何研究突出了塑化模型的整体行为，与鼻腔通畅的健康受试者完全一致。鼻窦内药物沉积的结果清楚地表明，气溶胶可以穿透上颌窦。100 Hz 声频气流导致药物沉积在上颌窦的增加，具体取决于雾化条件，增加了 2-3 倍。强调了活性物质在不同上颌窦口解剖特征和药物浓度下的差异沉积。
提出了一种与声频气流输送的雾化颗粒穿透的特殊传输机制的存在。
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