El Merhie Amira, Navarro Laurent, Delavenne Xavier, Leclerc Lara, Pourchez Jérémie
Ecole Nationale Supérieure des Mines, CIS-EMSE, Sainbiose UMR INSERM 1059, SFR FED 4166 - IFRESIS, F-42023, Saint-Etienne, France.
Laboratoire de Pharmacologie - Toxicologie, Sainbiose UMR INSERM 1059, CHU de Saint-Etienne, F-42055, Saint-Etienne, France.
Pharm Res. 2016 May;33(5):1074-84. doi: 10.1007/s11095-015-1851-7. Epub 2015 Dec 30.
Enhancement of intranasal sinus deposition involves nebulization of a drug superimposed by an acoustic airflow. We investigated the impact of fixed frequency versus frequency sweep acoustic airflow on the improvement of aerosolized drug penetration into maxillary sinuses.
Fixed frequency and frequency sweep acoustic airflow were generated using a nebulizing system of variable frequency. The effect of sweep cycle and intensity variation was studied on the intranasal sinus deposition. We used a nasal replica created from CT scans using 3D printing. Sodium fluoride and gentamicin were chosen as markers.
Studies performed using fixed frequency acoustic airflow showed that each of maxillary sinuses of the nasal replica required specific frequency for the optimal aerosol deposition. Intranasal sinus drug deposition experiments under the effect of the frequency sweep acoustic airflow showed an optimal aerosol deposition into both maxillary sinus of the nasal replica. Studies on the effect of the duration of the sweep cycle showed that the shorter the cycle the better the deposition.
We demonstrate the benefit of frequency sweep acoustic airflow on drug deposition into maxillary sinuses. However further in vivo studies have to be conducted since delivery rates cannot be obviously determined from a nasal replica.
增强鼻内鼻窦沉积涉及通过声流叠加对药物进行雾化。我们研究了固定频率与扫频声流对雾化药物渗透到上颌窦的改善作用。
使用可变频率的雾化系统产生固定频率和扫频声流。研究了扫频周期和强度变化对鼻内鼻窦沉积的影响。我们使用通过3D打印从CT扫描创建的鼻模型。选择氟化钠和庆大霉素作为标记物。
使用固定频率声流进行的研究表明，鼻模型的每个上颌窦都需要特定频率以实现最佳气溶胶沉积。在扫频声流作用下的鼻内鼻窦药物沉积实验表明，鼻模型的两个上颌窦均实现了最佳气溶胶沉积。对扫频周期持续时间影响的研究表明，周期越短沉积效果越好。
我们证明了扫频声流对药物在上颌窦沉积的益处。然而，由于无法从鼻模型中明显确定输送速率，因此必须进行进一步的体内研究。
