Dept. of. Neurology and Neuroscience, Weill Cornell Medical College, 785 Mamaroneck Ave., White Plains, NY 10605, USA.
Dev Biol. 2011 Dec 1;360(1):123-31. doi: 10.1016/j.ydbio.2011.09.018. Epub 2011 Sep 22.
The Notch signaling pathway regulates metazoan development, in part, by directly controlling the transcription of target genes. For a given cellular context, however, only subsets of the known target genes are transcribed when the pathway is activated. Thus, there are context-dependent mechanisms that selectively maintain repression of target gene transcription when the Notch pathway is activated. This review focuses on molecular mechanisms that have been recently reported to mediate selective repression of Notch pathway target gene transcription. These mechanisms are essential for generating the complex spatial and temporal expression patterns of Notch target genes during development.
Notch 信号通路通过直接控制靶基因的转录来调节后生动物的发育，部分是通过直接控制靶基因的转录来调节后生动物的发育。然而，对于给定的细胞环境，当途径被激活时，只有已知靶基因的子集被转录。因此，当 Notch 途径被激活时，存在着依赖于上下文的机制，可以选择性地维持靶基因转录的抑制。本综述重点介绍了最近报道的介导 Notch 途径靶基因转录选择性抑制的分子机制。这些机制对于在发育过程中产生 Notch 靶基因的复杂时空表达模式是必不可少的。
