Department of Biochemistry, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110 054, India.
J Ethnopharmacol. 2011 Nov 18;138(2):268-78. doi: 10.1016/j.jep.2011.09.024. Epub 2011 Sep 22.
ETHNOPHARMACOLOGICAL CONTEXT: This review explores the medicinal and therapeutic applications of Sea buckthorn (Hippophae rhamnoides L.) in curtailing different types of acute as well as chronic maladies. The plant is being used in different parts of the world for its nutritional and medicinal properties.
Sea buckthorn based preparations have been extensively exploited in folklore treatment of slow digestion, stomach malfunctioning, cardiovascular problems, liver injury, tendon and ligament injuries, skin diseases and ulcers. In the recent years, medicinal and pharmacological activities of Sea buckthorn have been well investigated using various in vitro and in vivo models as well as limited clinical trials.
Sea buckthorn has been scientifically analyzed and many of its traditional uses have been established using several biochemical and pharmacological studies. Various pharmacological activities such as cytoprotective, anti-stress, immunomodulatory, hepatoprotective, radioprotective, anti-atherogenic, anti-tumor, anti-microbial and tissue regeneration have been reported.
It is clear that Sea buckthorn is an important plant because of its immense medicinal and therapeutic potential. However, several knowledge gaps identified in this paper would give impetus to new academic and R&D activities especially for the development of Sea buckthorn based herbal medicine and nutraceuticals.
民族药理学背景：本综述探讨了沙棘（ Hippophae rhamnoides L. ）在治疗各种急性和慢性疾病方面的药用和治疗应用。该植物因其营养和药用特性而在世界不同地区被使用。
沙棘制剂在民间医学中被广泛用于治疗消化不良、肠胃功能紊乱、心血管问题、肝损伤、肌腱和韧带损伤、皮肤病和溃疡。近年来，使用各种体外和体内模型以及有限的临床试验对沙棘的药用和药理学活性进行了广泛研究。
沙棘已被科学分析，其许多传统用途已通过多项生化和药理学研究得到证实。已报道了多种药理活性，如细胞保护、抗应激、免疫调节、保肝、辐射防护、抗动脉粥样硬化、抗肿瘤、抗菌和组织再生。
很明显，沙棘因其巨大的药用和治疗潜力而成为一种重要的植物。然而，本文中确定的几个知识空白将为新的学术和研发活动提供动力，特别是开发基于沙棘的草药和营养保健品。
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