Sinha Ankita, Jain Parag
Department of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, India.
Rungta College of Engineering and Technology, Bhilai, India.
Inflammopharmacology. 2025 Jul 25. doi: 10.1007/s10787-025-01858-z.
Wound healing is a physiological process that has multiple phases of inflammation, proliferation, and remodeling that all need to be conducted in a coordinated manner by different cell types, cytokines, and signalling pathways. Recent developments in herbal medicine have shown the therapeutic potential of natural compounds in the augmentation of wound healing by regulation of molecular pathways and receptor targets. This narrative review addresses the wound healing role of herbal medicine using specific examples of growth factor receptors such as Epidermal Growth Factor Receptor, Transforming Growth Factor-β Receptor, Vascular Endothelial Growth Factor Receptor, and Fibroblast Growth Factor Receptor. Immune receptors including Toll-like Receptors and NOD-like Receptors are also involved in regulation of inflammation and immune response during wound healing. In addition, the review addresses the role of neurotransmitter receptors in pain relief and healing of wounds. Some of the herbal extracts, including Aloe vera, Calendula officinalis, Curcuma longa, honey, and Centella asiatica, have shown very good wound-healing activity owing to their antioxidant, anti-inflammatory, and antimicrobial properties. The comparative analysis of plant-derived and animal-derived natural drugs also focuses on their curative potency in wound healing. Thus, information regarding molecular mechanisms associated with the use of herbal medicine in wound healing may help in the development of novel therapeutic strategies for chronic and non-healing wounds.
伤口愈合是一个生理过程，具有炎症、增殖和重塑等多个阶段，所有这些阶段都需要由不同的细胞类型、细胞因子和信号通路以协调的方式进行。草药医学的最新进展表明，天然化合物通过调节分子途径和受体靶点，在促进伤口愈合方面具有治疗潜力。本叙述性综述通过表皮生长因子受体、转化生长因子-β受体、血管内皮生长因子受体和成纤维细胞生长因子受体等生长因子受体的具体例子，探讨了草药医学在伤口愈合中的作用。包括Toll样受体和NOD样受体在内的免疫受体也参与伤口愈合过程中的炎症调节和免疫反应。此外，该综述还探讨了神经递质受体在伤口疼痛缓解和愈合中的作用。一些草药提取物，包括芦荟、金盏花、姜黄、蜂蜜和积雪草，由于其抗氧化、抗炎和抗菌特性，已显示出非常好的伤口愈合活性。对植物源和动物源天然药物的比较分析也侧重于它们在伤口愈合方面的治疗效力。因此，有关草药医学在伤口愈合中应用的分子机制的信息可能有助于开发针对慢性和难愈合伤口的新型治疗策略。
