Cardiovascular and GastroIntestinal Research Area, AstraZeneca R&D Mölndal, SE-43183 Mölndal, Sweden.
Drug Discov Today. 2012 Jan;17(1-2):56-62. doi: 10.1016/j.drudis.2011.09.012. Epub 2011 Sep 22.
In drug discovery, the central process of constructing and testing hypotheses, carefully conducting experiments and analysing the associated data for new findings and information is known as the design-make-test-analyse cycle. Each step relies heavily on the inputs and outputs of the other three components. In this article we report our efforts to improve and integrate all parts to enable smooth and rapid flow of high quality ideas. Key improvements include enhancing multi-disciplinary input into 'Design', increasing the use of knowledge and reducing cycle times in 'Make', providing parallel sets of relevant data within ten working days in 'Test' and maximising the learning in 'Analyse'.
在药物研发中，构建和检验假说、精心开展实验以及分析相关数据以发现新发现和信息的核心过程被称为设计-制作-测试-分析循环。每个步骤都严重依赖于其他三个组件的输入和输出。在本文中，我们报告了我们为改进和整合所有部分以实现高质量想法的顺畅和快速流动所做的努力。主要改进包括增强“设计”的多学科投入，增加“制作”中知识的使用并减少循环时间，在“测试”中提供十日内相关数据的平行集，并最大限度地利用“分析”中的学习。
