Alexandru Ioan Cuza University, Laboratory of Animal Physiology, Iasi, Romania.
Psychiatr Danub. 2011 Sep;23(3):237-45.
Oxidative stress is the condition arising from imbalance between toxic reactive oxygen species and antioxidant systems. It is believed that increased oxidative stress may be relevant to the pathophysiology of schizophrenia. In this way, the main markers of the lipid peroxidation processes include 4-hydroxynonenal and malondialdehyde. On the other side, the potential toxicity of free radicals is counteracted by a number of cytoprotective antioxidant enzymes that limit the damage, such as superoxide dismutase and glutathione peroxidase. However, the reports regarding the status of oxidative stress markers schizophrenia are very inconsistent, with various authors stating both increased and decreased activities of the main antioxidant enzymes, while others did not observe any significant modifications, as compared to control groups. Similar aspects were also reported in the case of the lipid peroxidation markers, although in here the contradictions are much more reduced than in the case of the antioxidant defences. It is generally believed that the equivocal results mentioned above may be due to different tissues studies, different species or the administrated treatment and the duration of the disease/treatment. In this context, in the present paper we were interested to review some studies regarding the oxidative stress status in patients and animal models of schizophrenia, by referring mainly to antioxidant enzymes and lipid peroxidation markers.
氧化应激是由于毒性活性氧物种和抗氧化系统之间失衡而产生的状态。人们认为，氧化应激的增加可能与精神分裂症的病理生理学有关。在这种情况下，脂质过氧化过程的主要标志物包括 4-羟壬烯醛和丙二醛。另一方面，自由基的潜在毒性可以通过多种细胞保护抗氧化酶来抵消，这些酶可以限制损伤，如超氧化物歧化酶和谷胱甘肽过氧化物酶。然而，关于氧化应激标志物在精神分裂症中的状态的报告非常不一致，不同的作者报告了主要抗氧化酶的活性增加和减少，而其他作者则没有观察到与对照组相比有任何显著的变化。脂质过氧化标志物的情况也类似，尽管这里的矛盾比抗氧化防御的情况要少得多。人们普遍认为，上述不确定的结果可能是由于不同的组织研究、不同的物种或所给予的治疗以及疾病/治疗的持续时间不同所致。在这方面，在本文中，我们通过主要参考抗氧化酶和脂质过氧化标志物，对一些关于精神分裂症患者和动物模型的氧化应激状态的研究进行了综述。
