Yıldırım Demirdöğen Esen, Tanrıverdi Çiğdem, Kara İhsan, Donbaloğlu Mehmet Ali, Özgeriş Fatma Betül
Department of Child and Adolescent Psychiatry, Atatürk University Faculty of Medicine, Erzurum, TUR.
Department of Child and Adolescent Psychiatry, Erzurum Regional Training and Research Hospital, Erzurum, TUR.
Cureus. 2024 Feb 23;16(2):e54796. doi: 10.7759/cureus.54796. eCollection 2024 Feb.
Background It is important to determine the possible related factors of anxiety disorder, one of the common psychiatric disorders of childhood. Our aims in this study were to compare oxidative stress markers between anxiety disorders in pediatric patients and healthy controls and to examine the relationship between anxiety symptom severity and oxidative stress indicators. Methods The study included 25 patients and 25 healthy controls. We measured the total oxidant capacity (TOS) and total antioxidant capacity (TAS) from the collected serum samples and calculated the oxidative stress index (OSI). We evaluated the clinical severity of the anxiety symptoms by the Revised Child Anxiety and Depression Scale-Child Version (RCADS-CV). Results The groups did not exhibit a noteworthy distinction in terms of TOS (p=0.128) and TAS (p=0.329). However, OSI was markedly elevated in the group with anxiety disorder (p=0.044). In the correlation analysis between anxiety symptom severity and oxidative stress indicators in the group with anxiety disorder, we found a positive correlation between TOS and RCADS total anxiety score (p=0.08). Conclusion These results may point to an oxidative dysfunction in anxiety disorders and the potential role of oxidative stress in their aetiology. Prospective, large-scale, randomized studies are needed to investigate if oxidative stress indicators can be used in the diagnosis of anxiety disorders and as new treatment targets.
确定焦虑症（儿童常见精神疾病之一）的可能相关因素很重要。本研究的目的是比较儿科焦虑症患者与健康对照者之间的氧化应激标志物，并研究焦虑症状严重程度与氧化应激指标之间的关系。方法：该研究纳入了25例患者和25名健康对照者。我们从采集的血清样本中测量了总氧化能力（TOS）和总抗氧化能力（TAS），并计算了氧化应激指数（OSI）。我们通过修订版儿童焦虑与抑郁量表儿童版（RCADS-CV）评估焦虑症状的临床严重程度。结果：两组在TOS（p = 0.128）和TAS（p = 0.329）方面没有显著差异。然而，焦虑症组的OSI显著升高（p = 0.044）。在焦虑症组中焦虑症状严重程度与氧化应激指标的相关性分析中，我们发现TOS与RCADS总焦虑评分之间存在正相关（p = 0.08）。结论：这些结果可能表明焦虑症存在氧化功能障碍，以及氧化应激在其病因学中的潜在作用。需要进行前瞻性、大规模、随机研究，以调查氧化应激指标是否可用于焦虑症的诊断以及作为新的治疗靶点。
