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本文引用的文献

1
Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1.Grx4单硫醇谷氧还蛋白是铁限制依赖性抑制Fep1所必需的。
Eukaryot Cell. 2011 May;10(5):629-45. doi: 10.1128/EC.00015-11. Epub 2011 Mar 18.
2
A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans.荚膜独立吞噬抑制机制在新型隐球菌感染哺乳动物中的主要作用。
Cell Host Microbe. 2011 Mar 17;9(3):243-251. doi: 10.1016/j.chom.2011.02.003.
3
Preventing the ubiquitin-proteasome-dependent degradation of frataxin, the protein defective in Friedreich's ataxia.防止泛素-蛋白酶体依赖性降解 frataxin，这种蛋白在弗里德里希共济失调中存在缺陷。
Hum Mol Genet. 2011 Apr 1;20(7):1253-61. doi: 10.1093/hmg/ddq566. Epub 2011 Jan 7.
4
Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation.肠 DMT1 协同转运蛋白通过蛋白酶体内化和降解被铁调素下调。
Gastroenterology. 2011 Apr;140(4):1261-1271.e1. doi: 10.1053/j.gastro.2010.12.037. Epub 2011 Jan 1.
5
HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans.HapX 正向和负向调控新生隐球菌中铁饥饿诱导的转录反应。
PLoS Pathog. 2010 Nov 24;6(11):e1001209. doi: 10.1371/journal.ppat.1001209.
6
SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis.SREB，一种 GATA 转录因子，指导皮炎芽生菌中的不同命运，包括形态发生和铁载体生物合成。
PLoS Pathog. 2010 Apr 1;6(4):e1000846. doi: 10.1371/journal.ppat.1000846.
7
Control of iron homeostasis by an iron-regulated ubiquitin ligase.铁稳态的调控由一个铁调节的泛素连接酶来完成。
Science. 2009 Oct 30;326(5953):718-21. doi: 10.1126/science.1176333. Epub 2009 Sep 17.
8
Role of ferroxidases in iron uptake and virulence of Cryptococcus neoformans.铁氧化酶在新型隐球菌铁摄取和毒力中的作用。
Eukaryot Cell. 2009 Oct;8(10):1511-20. doi: 10.1128/EC.00166-09. Epub 2009 Aug 21.
9
Iron activates in vivo DNA binding of Schizosaccharomyces pombe transcription factor Fep1 through its amino-terminal region.铁通过其氨基末端区域激活粟酒裂殖酵母转录因子Fep1的体内DNA结合。
Eukaryot Cell. 2009 Apr;8(4):649-64. doi: 10.1128/EC.00001-09. Epub 2009 Feb 27.
10
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS.对全球感染艾滋病毒/艾滋病者中隐球菌性脑膜炎当前负担的估计。
AIDS. 2009 Feb 20;23(4):525-30. doi: 10.1097/QAD.0b013e328322ffac.

铁影响真菌病原体新型隐球菌中铁调节蛋白 Cir1 的丰度。

Iron influences the abundance of the iron regulatory protein Cir1 in the fungal pathogen Cryptococcus neoformans.

机构信息

Department of Biotechnology, Chung-Ang University, Anseong-Si, Gyeonggi-Do, Republic of Korea.

出版信息

FEBS Lett. 2011 Oct 20;585(20):3342-7. doi: 10.1016/j.febslet.2011.09.025. Epub 2011 Sep 29.

DOI:10.1016/j.febslet.2011.09.025
PMID:21963719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3200532/
Abstract

The GATA-type, zinc-finger protein Cir1 regulates iron uptake, iron homeostasis and virulence factor expression in the fungal pathogen Cryptococcus neoformans. The mechanisms by which Cir1 senses iron availability, although as yet undefined, are important for understanding the proliferation of the fungus in mammalian hosts. We investigated the influence of iron availability on Cir1 and found that the abundance of the protein decreases upon iron deprivation. This destabilization was influenced by reducing conditions and by inhibition of proteasome function. The combined data suggest a post-translational mechanism for the control of Cir1 abundance in response to iron and redox status.

摘要

GATA 型锌指蛋白 Cir1 调控真菌病原体新生隐球菌中铁的摄取、铁稳态和毒力因子表达。虽然 Cir1 感知铁可用性的机制尚未确定，但对于理解真菌在哺乳动物宿主中的增殖非常重要。我们研究了铁可用性对 Cir1 的影响，发现铁缺乏时蛋白质的丰度降低。这种不稳定性受还原条件和蛋白酶体功能抑制的影响。综合数据表明，Cir1 丰度的调控存在一种针对铁和氧化还原状态的翻译后机制。