Department of Medical Research, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
Oncogene. 2012 May 17;31(20):2499-511. doi: 10.1038/onc.2011.444. Epub 2011 Oct 3.
The recent upsurge of interest in microRNA (miRNA) is partly attributed to the discovery of the novel roles of miRNAs in many physiological and pathological processes, including tumor development. Research on breast cancer metastasis has also focused on the concept of miRNA, which can act either as promoters or as suppressors of metastases. This review will focus on a series of recent studies that demonstrate the involvement of miRNAs in breast cancer metastasis and will briefly describe various pathways of miRNA-regulated metastasis. Finally, future prospects will be discussed for the potential role of miRNAs as predictive markers and therapeutic agents for patients with breast cancer metastases.
近期人们对 microRNA（miRNA）的兴趣大增，部分原因是发现 miRNA 在许多生理和病理过程中发挥了新的作用，包括肿瘤的发生发展。乳腺癌转移的研究也集中在 miRNA 的概念上，miRNA 可以作为转移的促进因子或抑制因子。本综述将重点介绍一系列最近的研究，这些研究表明 miRNA 参与了乳腺癌的转移，并简要描述了 miRNA 调控转移的各种途径。最后，还将讨论 miRNA 作为预测标志物和治疗剂用于乳腺癌转移患者的潜在作用。
