Oncogene. 2012 Jun 7;31(23):2805-8. doi: 10.1038/onc.2011.459. Epub 2011 Oct 3.
Chemo- and radio-therapeutic regimens frequently kill cancer cells by inducing apoptosis, a cell-death subroutine that involves the activation of a particular class of proteases called caspases. In a recent issue of Nature Medicine, Huang et al. (2011) show that caspase activation in dying tumor cells causes the release of soluble lipid messengers, notably prostaglandin E(2), that stimulate tumor cell proliferation. In this short review, we will discuss the clinical and therapeutic implications of these findings.
化疗和放疗方案通过诱导细胞凋亡来杀死癌细胞，细胞凋亡是一种涉及特定蛋白酶（称为半胱天冬酶）激活的细胞死亡程序。在《自然医学》的最近一期上，Huang 等人（2011）表明，死亡肿瘤细胞中的半胱天冬酶激活会导致可溶性脂质信使（特别是前列腺素 E2）的释放，从而刺激肿瘤细胞增殖。在这篇简短的综述中，我们将讨论这些发现的临床和治疗意义。
