在大肠杆菌中产生的乙型肝炎病毒X蛋白具有生物学功能。
Hepatitis B virus X protein produced in Escherichia coli is biologically functional.
作者信息
Jameel S, Siddiqui A, Maguire H F, Rao K V
机构信息
Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
出版信息
J Virol. 1990 Aug;64(8):3963-6. doi: 10.1128/JVI.64.8.3963-3966.1990.
Abstract
The hepatitis B virus X gene product trans activates transcription from a variety of viral and cellular regulatory elements. We expressed the complete, nonfused X protein in Escherichia coli and showed it to be active in trans activating a human immunodeficiency virus long terminal repeat-linked chloramphenicol acetyltransferase reporter gene.
摘要
乙肝病毒X基因产物可反式激活来自多种病毒和细胞调控元件的转录。我们在大肠杆菌中表达了完整的、未融合的X蛋白，并证明它在反式激活与人类免疫缺陷病毒长末端重复序列相连的氯霉素乙酰转移酶报告基因方面具有活性。
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