Ophthalmic Research Center and Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cornea. 2012 Jan;31(1):84-6. doi: 10.1097/ICO.0b013e31821821af.
To report the clinical features and histopathology of a transplanted cornea that was immediately replaced because of the possible diagnosis of lattice corneal dystrophy in the graft in which histopathologic examination revealed a Zygomycetes infection.
A 19-year-old patient with keratoconus underwent deep anterior lamellar keratoplasty (DALK) in the right eye. The operation was uneventful, transplanting a corneal graft without Descemet membrane, harvested from a donor with signs of orbital trauma.
Three days after keratoplasty, multiple refractile lines involving the entire donor stroma were observed. With the potential diagnosis of lattice dystrophy of the donor cornea, the graft was replaced and sent for histopathologic analysis, which revealed a Zygomycetes graft infection.
This case report introduces Zygomycetes as a cause of donor-to-host infection and also suggests that corneas harvested from donors with signs of orbital trauma may be a risk factor for donor-to-recipient transmission of such fungal infections.
报告一例因疑似移植片中存在格子状角膜营养不良而立即更换的移植角膜的临床特征和组织病理学。组织病理学检查显示为蕈样真菌感染。
一名 19 岁的圆锥角膜患者右眼行深板层角膜移植术（DALK）。手术过程顺利，移植了一片未带有后弹力层的角膜，供体有眼眶外伤的迹象。
角膜移植术后 3 天，发现整个供体基质中出现多处折光性线。考虑到供体角膜格子状营养不良的可能诊断，更换了移植物，并进行了组织病理学分析，结果显示为蕈样真菌移植物感染。
本病例报告介绍了蕈样真菌是供体到宿主感染的原因，并提示来自有眼眶外伤迹象的供体的角膜可能是此类真菌感染从供体到受者传播的一个危险因素。
