Koenig Steven B, Wirostko William J, Fish Robert I, Covert Douglas J
Eye Institute, Froedtert and The Medical College of Wisconsin, Milwaukee, WI, USA.
Cornea. 2009 May;28(4):471-3. doi: 10.1097/ICO.0b013e31818ad9bc.
To report the donor-to-host transmission of Candida albicans after Descemet stripping and automated endothelial keratoplasty (DSAEK).
An 80-year-old woman with pseudophakic bullous keratopathy developed an infiltrate in the donor corneal lenticule after DSAEK.
Donor corneoscleral rim cultures grew C. albicans. Gram stain of the removed corneal lenticule demonstrated budding yeast and pseudohyphae, and cultures yielded C. albicans. Despite topical and systemic antifungal therapy and therapeutic penetrating keratoplasty, the patient developed a blind painful eye and underwent enucleation.
This case report indicates that fungal keratitis may occur from donor-to-host transmission after DSAEK. The location of the infected tissue poses diagnostic and therapeutic challenges for the surgeon.
报告在深板层角膜内皮移植术（DSAEK）后白色念珠菌从供体向宿主的传播情况。
一名患有假晶状体大泡性角膜病变的80岁女性在DSAEK术后供体角膜植片中出现浸润。
供体角膜巩膜缘培养物生长出白色念珠菌。移除的角膜植片革兰氏染色显示出芽酵母和假菌丝，培养物也培养出白色念珠菌。尽管进行了局部和全身抗真菌治疗以及治疗性穿透性角膜移植术，患者仍发展为失明且疼痛的眼睛，最终接受了眼球摘除术。
本病例报告表明DSAEK术后可能发生真菌从供体向宿主的传播导致真菌性角膜炎。感染组织的位置给外科医生带来了诊断和治疗挑战。
