Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University, China.
Acta Pharmacol Sin. 2011 Nov;32(11):1351-6. doi: 10.1038/aps.2011.118. Epub 2011 Oct 3.
To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction (STEMI).
A total of 231 consecutive patients (177 males, 54 females) with STEMI were enrolled. Anthropometric and laboratory measurements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine (FT4), and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer.
Patients were classified into 4 groups according to their quartile FT3 and FT4 levels: 0.40-3.09 (n=52), 3.10-3.69 (n=56), 3.70-4.29 (n=64) and 4.30-7.10 (n=59) for FT3; 4.9-14.8 (n=57), 14.9-16.8 (n=58), 16.9-18.7 (n=57) and 18.8-29.0 (n=59) for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level (P=0.01). Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values (β=-0.139, P=0.025). The value of INR was similar among the 4 groups according to the quartile FT4 levels (P=0.36).
Free triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function.
探讨中国甲状腺功能正常的急性 ST 段抬高型心肌梗死（STEMI）患者游离三碘甲状腺原氨酸（FT3）与国际标准化比值（患者凝血酶原时间与正常样本的比值，INR）之间的关系。
共纳入 231 例连续 STEMI 患者（男 177 例，女 54 例）。记录所有患者的人口学和实验室测量值，包括心率、呼吸频率、血压、体温、血小板计数、INR、凝血酶原时间、活化部分凝血活酶时间、FT3、游离甲状腺素（FT4）和促甲状腺激素。使用全自动免疫分析仪检测 FT3 和 FT4 水平，使用凝血分析仪检测 INR。
根据 FT3 和 FT4 四分位水平，患者被分为 4 组：FT3 第 0.40-3.09 四分位数组（n=52）、FT3 第 3.10-3.69 四分位数组（n=56）、FT3 第 3.70-4.29 四分位数组（n=64）和 FT3 第 4.30-7.10 四分位数组（n=59）；FT4 第 4.9-14.8 四分位数组（n=57）、FT4 第 14.9-16.8 四分位数组（n=58）、FT4 第 16.9-18.7 四分位数组（n=57）和 FT4 第 18.8-29.0 四分位数组（n=59）。与 FT3 低四分位数组相比，FT3 高四分位数组的 INR 值显著更低（P=0.01）。多元线性回归分析显示，血清 FT3 降低是 INR 值升高的独立危险因素（β=-0.139，P=0.025）。根据 FT4 四分位水平，INR 值在 4 组间无显著差异（P=0.36）。
在甲状腺功能正常的急性 STEMI 患者中，游离三碘甲状腺原氨酸与 INR 呈负相关。
