Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil.
Prog Neurobiol. 2011 Nov;95(3):396-405. doi: 10.1016/j.pneurobio.2011.09.006. Epub 2011 Sep 22.
The relationship between sleep and epilepsy has been known since ancient times, and the modulating effects of both on each other have been widely described in clinical studies. However, the mechanisms of this correlation remain unclear. Translational research is essential for filling the gaps in our knowledge, and for developing better therapeutic approaches to improve the quality of life of epileptic patients. Excellent animal models of epilepsy are available for the investigation of various aspects of epilepsy, such as epileptogenesis and hippocampal sclerosis. These models also show an association between sleep and epilepsy, suggesting that they are suitable for translational research on this relationship. While some knowledge has been obtained from preclinical studies, the topic remains relatively unexplored. In terms of the role of sleep in modulating seizure susceptibility in epilepsy, animal sleep research is a major tool. In this review, we focus on the intricate relationship between sleep and epilepsy in the preclinical setting, using a translational science approach.
自古以来，人们就已经认识到睡眠与癫痫之间存在关系，并且在临床研究中广泛描述了两者之间的相互调节作用。然而，这种相关性的机制仍不清楚。转化研究对于填补我们知识中的空白以及开发更好的治疗方法以提高癫痫患者的生活质量至关重要。对于癫痫的各个方面，例如癫痫发生和海马硬化，都有优秀的癫痫动物模型可用于研究。这些模型还显示出睡眠与癫痫之间的关联，表明它们适合于针对这种关系的转化研究。尽管从临床前研究中获得了一些知识，但该主题仍相对未得到充分探索。就睡眠在调节癫痫发作易感性中的作用而言，动物睡眠研究是一个主要工具。在这篇综述中，我们使用转化科学方法，重点关注临床前环境中睡眠与癫痫之间复杂的关系。
