Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA.
Nat Chem Biol. 2011 Oct 2;7(11):766-8. doi: 10.1038/nchembio.667.
Cytokinins are classic hormones that orchestrate plant growth and development and the integrity of stem cell populations. Cytokinin receptors are eukaryotic sensor histidine kinases that are activated by both naturally occurring adenine-type cytokinins and urea-based synthetic compounds. Crystal structures of the Arabidopsis thaliana histidine kinase 4 sensor domain in complex with different cytokinin ligands now rationalize the hormone-binding specificity of the receptor and may spur the design of new cytokinin ligands.
细胞分裂素是经典的激素，它们协调植物的生长和发育以及干细胞群体的完整性。细胞分裂素受体是真核传感器组氨酸激酶，它被天然存在的腺嘌呤型细胞分裂素和基于尿素的合成化合物激活。拟南芥组氨酸激酶 4 传感器结构域与不同细胞分裂素配体复合物的晶体结构现在使受体的激素结合特异性合理化，并且可能激发新的细胞分裂素配体的设计。
