中枢神经系统药物发现中转基因动物的应用概述。
Overview of the use of transgenic animals in CNS drug discovery.
作者信息
Nestler E J, Olivier B
机构信息
Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut, USA.
出版信息
Curr Protoc Pharmacol. 2001 May;Chapter 5:Unit5.20. doi: 10.1002/0471141755.ph0520s07.
PMID:21965073
Abstract
This overview highlights how transgenic mice, and related genetic manipulations, can contribute in important ways to the goal of developing novel treatments for neuropsychiatric disorders. A brief background of the field of drug discovery is covered and then new animal models of CNS disorders are discussed along with the topics of target validation, identification of novel targets, and functional genomics.
摘要
本综述着重介绍了转基因小鼠及相关基因操作如何以重要方式推动针对神经精神疾病开发新疗法这一目标的实现。文中涵盖了药物发现领域的简要背景，随后讨论了中枢神经系统疾病的新型动物模型，以及靶点验证、新靶点识别和功能基因组学等主题。
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