Khan Kanza M, Collier Adam D, Meshalkina Darya A, Kysil Elana V, Khatsko Sergey L, Kolesnikova Tatyana, Morzherin Yury Yu, Warnick Jason E, Kalueff Allan V, Echevarria David J
Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA.
The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
Br J Pharmacol. 2017 Jul;174(13):1925-1944. doi: 10.1111/bph.13754. Epub 2017 Apr 5.
Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets.
尽管神经精神疾病的患病率很高，但其病因和分子机制仍知之甚少。斑马鱼（Danio rerio）在神经药理学研究和体内药物筛选中越来越多地被用作强大的动物模型。总体而言，这使斑马鱼成为药物发现和识别紊乱分子途径的有用工具。在这里，我们讨论了选定的人类神经精神疾病和药物诱导表型的斑马鱼模型。除了涵盖广泛的脑部疾病（从焦虑症和精神病到神经退行性疾病），我们还总结了斑马鱼遗传学和小分子筛选的最新进展，这些进展显著增强了疾病建模和新药物靶点的发现。
