Ignjatovic Vera, Chandramouli Aparajith, Than Jenny, Summerhayes Robyn, Newall Fiona, Horton Steve, Cochrane Andrew, Monagle Paul
Murdoch Childrens Research Institute, Parkville, Australia.
Pediatr Cardiol. 2012 Feb;33(2):280-5. doi: 10.1007/s00246-011-0122-6. Epub 2011 Oct 2.
This prospective, single-centre cohort study aimed to evaluate plasmin generation and fibrinolysis during and after cardiopulmonary bypass (CPB) surgery in a cohort of children up to 6 years of age. Blood samples were drawn at eight time points: after induction of anesthesia, before unfractionated heparin (UFH), after UFH, after initiation of bypass, before protamine, after protamine, after chest closure, and 6 h after chest closure. The study identified an increase in fibrinolysis during CPB and particularly up to 6 h afterward in children. This could be the mechanism for the significant bleeding events observed in this young population after CPB. This study establishes the foundation for future studies in this area, particularly those focusing on clinical outcomes after CPB surgery.
这项前瞻性、单中心队列研究旨在评估6岁及以下儿童在体外循环（CPB）手术期间及术后的纤溶酶生成和纤维蛋白溶解情况。在八个时间点采集血样：麻醉诱导后、未用普通肝素（UFH）前、用UFH后、开始体外循环后、用鱼精蛋白前、用鱼精蛋白后、关胸后以及关胸后6小时。该研究发现，儿童在体外循环期间，尤其是术后6小时内，纤维蛋白溶解增加。这可能是该年轻人群在体外循环后发生显著出血事件的机制。这项研究为该领域的未来研究奠定了基础，尤其是那些关注体外循环手术后临床结局的研究。
