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开放性部分肾切除术。个人技术与当前疗效

Open partial nephrectomy. Personal technique and current outcomes.

作者信息

Russo Paul

机构信息

Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.

出版信息

Arch Esp Urol. 2011 Sep;64(7):571-93.

PMID:21965255
Abstract

Modern imaging capabilities has created a renal tumor stage and size migration with approximately 70% of patients today detected incidentally with a median tumor size of 4cm or less. In addition, our current understanding indicates that renal cortical tumors are a family of neoplasms with distinct histopathological and cytogenetic features and variable metastatic potential.The conventional clear cell tumor has a malignant potential and accounts for only 54% of the total renal cortical tumors but 90% of those that metastasize. Radical nephrectomy, whether performed by open or minimally invasive surgical technique, plays an important role in the management of massive renal tumors that have replaced the normal renal parenchyma, invade the the renal vein, and have associated regional lymphadenopathy or metastatic disease. Partial nephrectomy has emerged as the treatment of choice for patients with smaller tumors. This operation can be performed through a "miniflank" surgical incision without rib resection. Complications related to partial nephrectomy, including bleeding, urinary fistula and infection occur in less than 10% of cases. Radical nephrectomy should not be performed for the treatment of small renal tumors since it is associated with the causation or worsening of preexisting CKD which can cause an increased likelihood of cardiovascular morbidity and mortality. Despite a wealth of evidence supporting the more restricted indications for RN, strong evidence exists that it remains over utilized in the United States. Widespread education and training in kidney preserving surgical strategies is essential going forward.

摘要

现代成像技术导致了肾肿瘤分期和大小的变化,如今约70%的患者是偶然发现肾肿瘤的,肿瘤中位大小为4厘米或更小。此外,我们目前的认识表明,肾皮质肿瘤是一组具有不同组织病理学和细胞遗传学特征以及不同转移潜能的肿瘤。传统的透明细胞肿瘤具有恶性潜能,仅占肾皮质肿瘤总数的54%,但在发生转移的肿瘤中占90%。根治性肾切除术,无论是通过开放手术还是微创手术技术进行,在治疗已取代正常肾实质、侵犯肾静脉并伴有区域淋巴结病或转移疾病的巨大肾肿瘤方面都发挥着重要作用。部分肾切除术已成为较小肿瘤患者的首选治疗方法。该手术可通过“小腰部”手术切口进行,无需切除肋骨。与部分肾切除术相关的并发症,包括出血、尿瘘和感染,发生率不到10%。不应采用根治性肾切除术治疗小肾肿瘤,因为它会导致原有慢性肾脏病的发生或恶化,进而增加心血管疾病发病和死亡的可能性。尽管有大量证据支持对根治性肾切除术的适应证进行更严格限制,但有力证据表明,在美国,该手术仍被过度使用。今后,广泛开展肾脏保留手术策略的教育和培训至关重要。

相似文献

1
Open partial nephrectomy. Personal technique and current outcomes.开放性部分肾切除术。个人技术与当前疗效
Arch Esp Urol. 2011 Sep;64(7):571-93.
2
Open partial nephrectomy: an essential operation with an expanding role.开放性部分肾切除术:一项作用不断扩大的重要手术。
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Partial nephrectomy achieves local tumor control and prevents chronic kidney disease.部分肾切除术可实现局部肿瘤控制并预防慢性肾病。
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The medical and oncological rationale for partial nephrectomy for the treatment of T1 renal cortical tumors.对T1期肾皮质肿瘤进行部分肾切除术治疗的医学和肿瘤学理论依据。
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Surgery insight: advances in techniques for open partial nephrectomy.外科洞察:开放性部分肾切除术技术进展
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Renal functional outcomes after partial nephrectomy with extended ischemic intervals are better than after radical nephrectomy.肾部分切除术后延长缺血时间的肾功能结果优于根治性肾切除术。
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Renal cell carcinoma with renal vein and inferior vena caval involvement: clinicopathological features, surgical techniques and outcomes.累及肾静脉和下腔静脉的肾细胞癌:临床病理特征、手术技术及预后
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引用本文的文献

1
Long-Term Oncologic Outcomes After Laparoscopic and Robotic Tumor Enucleation for Renal Cell Carcinoma.腹腔镜和机器人辅助肾细胞癌肿瘤剜除术后的长期肿瘤学结局
Front Oncol. 2021 Jan 14;10:595457. doi: 10.3389/fonc.2020.595457. eCollection 2020.
2
Open partial nephrectomy: current review.开放性部分肾切除术:当前综述
Transl Androl Urol. 2020 Dec;9(6):3149-3159. doi: 10.21037/tau-20-474.
3
Open partial nephrectomy when a non-flank approach is required: indications and outcomes.当需要非腰部入路时行部分肾切除术:适应证和结果。
World J Urol. 2019 Mar;37(3):515-522. doi: 10.1007/s00345-018-2414-4. Epub 2018 Jul 24.