Russo Paul
Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.
Arch Esp Urol. 2011 Sep;64(7):571-93.
Modern imaging capabilities has created a renal tumor stage and size migration with approximately 70% of patients today detected incidentally with a median tumor size of 4cm or less. In addition, our current understanding indicates that renal cortical tumors are a family of neoplasms with distinct histopathological and cytogenetic features and variable metastatic potential.The conventional clear cell tumor has a malignant potential and accounts for only 54% of the total renal cortical tumors but 90% of those that metastasize. Radical nephrectomy, whether performed by open or minimally invasive surgical technique, plays an important role in the management of massive renal tumors that have replaced the normal renal parenchyma, invade the the renal vein, and have associated regional lymphadenopathy or metastatic disease. Partial nephrectomy has emerged as the treatment of choice for patients with smaller tumors. This operation can be performed through a "miniflank" surgical incision without rib resection. Complications related to partial nephrectomy, including bleeding, urinary fistula and infection occur in less than 10% of cases. Radical nephrectomy should not be performed for the treatment of small renal tumors since it is associated with the causation or worsening of preexisting CKD which can cause an increased likelihood of cardiovascular morbidity and mortality. Despite a wealth of evidence supporting the more restricted indications for RN, strong evidence exists that it remains over utilized in the United States. Widespread education and training in kidney preserving surgical strategies is essential going forward.
现代成像技术导致了肾肿瘤分期和大小的变化,如今约70%的患者是偶然发现肾肿瘤的,肿瘤中位大小为4厘米或更小。此外,我们目前的认识表明,肾皮质肿瘤是一组具有不同组织病理学和细胞遗传学特征以及不同转移潜能的肿瘤。传统的透明细胞肿瘤具有恶性潜能,仅占肾皮质肿瘤总数的54%,但在发生转移的肿瘤中占90%。根治性肾切除术,无论是通过开放手术还是微创手术技术进行,在治疗已取代正常肾实质、侵犯肾静脉并伴有区域淋巴结病或转移疾病的巨大肾肿瘤方面都发挥着重要作用。部分肾切除术已成为较小肿瘤患者的首选治疗方法。该手术可通过“小腰部”手术切口进行,无需切除肋骨。与部分肾切除术相关的并发症,包括出血、尿瘘和感染,发生率不到10%。不应采用根治性肾切除术治疗小肾肿瘤,因为它会导致原有慢性肾脏病的发生或恶化,进而增加心血管疾病发病和死亡的可能性。尽管有大量证据支持对根治性肾切除术的适应证进行更严格限制,但有力证据表明,在美国,该手术仍被过度使用。今后,广泛开展肾脏保留手术策略的教育和培训至关重要。