Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1-1, Kanokoden, Chikusa Nagoya, Aichi 464-8681, Japan.
Anticancer Res. 2011 Oct;31(10):3463-7.
We aimed to clarify the clinicopathological features of poorly differentiated colorectal adenocarcinomas and to define two subtypes of these adenocarcinomas.
We enrolled 78 patients, who had undergone surgery for poorly differentiated colorectal adenocarcinoma. On the basis of the microscopy results, the Por1 type is characterized by cancer cells with solid growth and little stroma; most cells contained round-shaped nuclei. The Por2 type is characterized by cancer cells with a predominantly trabecular structure; these tumors are rich in fibrous stroma. The two groups were compared for clinicopathological factors.
The frequency of metastasis of the lymph node, liver, lung, and peritoneum in the Por2 group was significantly higher than that in the Por1 group. The survival rate in the Por2 group was lower than that in the Por1 group.
The classification system described in this study is a simple and easy method for predicting poorly differentiated colorectal adenocarcinomas, and the prognosis of patients with Por2 tended to be unfavorable than that of Por1.
我们旨在阐明低分化结直肠腺癌的临床病理特征，并定义此类腺癌的两个亚型。
我们纳入了 78 名因低分化结直肠腺癌而行手术治疗的患者。根据显微镜结果，Por1 型的特征是癌细胞呈实性生长且间质较少；大多数细胞的细胞核呈圆形。Por2 型的特征是癌细胞呈明显的小梁状结构；这些肿瘤富含纤维间质。对两组的临床病理因素进行了比较。
Por2 组淋巴结、肝、肺和腹膜转移的频率明显高于 Por1 组。Por2 组的生存率低于 Por1 组。
本研究描述的分类系统是预测低分化结直肠腺癌的一种简单方法，Por2 型患者的预后比 Por1 型差。
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