Department of Urology, Medical University of Vienna, Allgemeines Krankenhaus, Wien 1090, Währinger Gürtel 18-20, Austria.
Anticancer Res. 2011 Oct;31(10):3615-8.
Data on testosterone levels of patients with prostate cancer of different grade and stage are inconsistent. We retrospectively investigated serum total testosterone of a radical prostatectomy cohort to further shed light on this problem.
The preoperative level of serum total testosterone of 217 patients (mean age: 65±5.8 years) undergoing radical prostatectomy between 1989 and 2002 was analyzed for possible associations with Gleason score (≤6 vs. <7 vs. 8-10) and tumor stage (pT2 vs. pT3 vs. N+) with adjustment for age, diabetes and obesity. Patients exhibiting prostate-specific antigen (PSA) levels of >10 ng/ml and biopsy Gleason scores of ≥7 were submitted to standard lymphadenectomy.
The multivariate model revealed a significant effect of body mass index (BMI) (p=0.0003) and diabetes (p=0.002) on testosterone levels. Significantly lower testosterone levels were recorded in patients with nodal metastases (p<0.0001) compared to patients with non metastatic disease. No significant associations between testosterone, Gleason score and stage were found in patients with non- metastatic disease.
Testosterone levels prior to radical prostatectomy were lower in patients with nodal involvement.
关于不同分级和分期前列腺癌患者的睾酮水平的数据不一致。我们回顾性调查了根治性前列腺切除术队列的血清总睾酮水平，以进一步阐明这个问题。
分析了 1989 年至 2002 年间接受根治性前列腺切除术的 217 例患者（平均年龄：65±5.8 岁）术前血清总睾酮水平与 Gleason 评分（≤6 vs. <7 vs. 8-10）和肿瘤分期（pT2 vs. pT3 vs. N+）的可能相关性，调整了年龄、糖尿病和肥胖因素。前列腺特异性抗原（PSA）水平>10ng/ml 和活检 Gleason 评分≥7 的患者接受标准淋巴结切除术。
多变量模型显示体重指数（BMI）（p=0.0003）和糖尿病（p=0.002）对睾酮水平有显著影响。与无淋巴结转移的患者相比，有淋巴结转移的患者的睾酮水平显著降低（p<0.0001）。在无淋巴结转移的患者中，睾酮水平与 Gleason 评分和分期之间无显著相关性。
在有淋巴结受累的患者中，根治性前列腺切除术前的睾酮水平较低。
