Salerno C, Crepaldi T, Savoia P, Richiardi P
Dipartimento di Genetica, Università degli Studi di Torino.
Ric Clin Lab. 1990 Apr-Jun;20(2):85-93. doi: 10.1007/BF02877554.
A decreased expression of major histocompatibility complex (MHC) class I antigens is a common feature of many experimental and human tumors and can often be correlated with malignancy grade. In fact, reduction of class I antigens is associated in most tumors with an enhanced ability to elude immune surveillance. Loss of HLA-A,B,C antigens ranges from a decrease in the percentage of A,B,C-positive cells to selective loss of particular antigens and total loss of class I molecule expression. In man, this has been documented in melanomas, carcinomas, lymphomas, neuroblastoma and acute leukemias. The reduction in membrane antigens is generally associated with a parallel fall in immunoprecipitable intracellular proteins and the corresponding mRNAs in the absence of structural changes in the coding genes. The literature concerning the above mentioned topics is reviewed and discussed.
主要组织相容性复合体（MHC）I类抗原表达降低是许多实验性肿瘤和人类肿瘤的共同特征，且常常与恶性程度相关。事实上，在大多数肿瘤中，I类抗原的减少与逃避免疫监视能力的增强有关。HLA - A、B、C抗原的丧失范围从A、B、C阳性细胞百分比的降低到特定抗原的选择性丧失以及I类分子表达的完全丧失。在人类中，这已在黑色素瘤、癌、淋巴瘤、神经母细胞瘤和急性白血病中得到证实。在编码基因无结构变化的情况下，膜抗原的减少通常与免疫沉淀的细胞内蛋白质及其相应mRNA的平行下降有关。本文对上述主题的文献进行了综述和讨论。
