Department of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland.
Br J Dermatol. 2012 Feb;166(2):279-87. doi: 10.1111/j.1365-2133.2011.10662.x.
Patients with papulopustular rosacea (PPR) frequently complain of dry, sensitive skin. We have previously demonstrated that patients with PPR have reduced skin surface hydration levels in the presence of normal sebum casual levels, suggesting that it may be the quality and not the quantity of sebum that plays a role in PPR.
To compare the sebaceous fatty acid composition of patients with PPR to that of controls with normal facial skin.
The sebaceous fatty acid composition of 25 patients with PPR and 24 age- and sex-matched controls was analysed by gas chromatography - mass spectrometry. Results Myristic acid (C14:0) was present in greater concentrations in PPR sebum, while the long chain saturated fatty acids arachidic acid (C20:0), behenic acid (C22:0), tricosanoic acid (C23:0) and lignoceric acid (C24:0) as well as the monounsaturated fatty acid cis-11-eicosanoic acid (C20:1) were present in the sebum of patients with PPR in lesser concentrations as compared with controls.
There is increasing evidence that sebaceous fatty acids play a role in the maintenance of skin barrier integrity. We have shown for the first time that patients with PPR have an abnormal sebaceous fatty acid composition, with reduced levels of long chain saturated fatty acids. These new findings may have therapeutic implications for the development of sebum-modifying nonantibiotic treatments for patients with PPR.
患有丘疹脓疱性酒渣鼻（PPR）的患者常抱怨皮肤干燥、敏感。我们之前的研究表明，即使皮脂正常分泌，PPR 患者的皮肤表面水合水平仍较低，这表明可能是皮脂的质量而不是数量在 PPR 中起作用。
比较 PPR 患者与正常面部皮肤的对照组的皮脂脂肪酸组成。
通过气相色谱-质谱法分析了 25 名 PPR 患者和 24 名年龄和性别匹配的对照组的皮脂脂肪酸组成。结果：肉豆蔻酸（C14:0）在 PPR 皮脂中的浓度更高，而长链饱和脂肪酸花生酸（C20:0）、山嵛酸（C22:0）、二十三烷酸（C23:0）和二十四烷酸（C24:0）以及单不饱和脂肪酸顺-11-二十烷酸（C20:1）在 PPR 患者的皮脂中的浓度较低。
越来越多的证据表明皮脂脂肪酸在维持皮肤屏障完整性中起作用。我们首次表明，PPR 患者的皮脂脂肪酸组成异常，长链饱和脂肪酸水平降低。这些新发现可能对开发非抗生素类皮脂调节剂治疗 PPR 患者具有治疗意义。
