Smith Robyn N, Braue Anna, Varigos George A, Mann Neil J
School of Applied Sciences, RMIT University, GPO Box 2476V, Melbourne, Victoria 3001, Australia.
J Dermatol Sci. 2008 Apr;50(1):41-52. doi: 10.1016/j.jdermsci.2007.11.005. Epub 2008 Jan 4.
Dietary factors have long been implicated in acne pathogenesis. It has recently been hypothesized that low glycemic load diets may influence sebum production based on the beneficial endocrine effects of these diets.
To determine the effect of a low glycemic load diet on acne and the fatty acid composition of skin surface triglycerides.
Thirty-one male acne patients (aged 15-25 years) completed sebum sampling tests as part of a larger 12-week, parallel design dietary intervention trial. The experimental treatment was a low glycemic load diet, comprised of 25% energy from protein and 45% from low glycemic index carbohydrates. In contrast, the control situation emphasized carbohydrate-dense foods without reference to the glycemic index. Acne lesion counts were assessed during monthly visits. At baseline and 12-weeks, the follicular sebum outflow and composition of skin surface triglycerides were assessed using lipid absorbent tapes.
At 12 weeks, subjects on the experimental diet demonstrated increases in the ratio of saturated to monounsaturated fatty acids of skin surface triglycerides when compared to controls [5.3+/-2.0% (mean+/-S.E.M.) vs. -2.7+/-1.7%, P=0.007]. The increase in the saturated/monounsaturated ratio correlated with acne lesion counts(r=-0.39, P=0.03). Increased follicular sebum outflow was also associated with an increase in the proportion of monounsaturated fatty acids in sebum (r=0.49, P=0.006).
This suggests a possible role of desaturase enzymes in sebaceous lipogenesis and the clinical manifestation of acne. However, further work is needed to clarify the underlying role of diet in sebum gland physiology.
饮食因素长期以来一直被认为与痤疮的发病机制有关。最近有假说认为，基于这些饮食有益的内分泌作用，低血糖负荷饮食可能会影响皮脂分泌。
确定低血糖负荷饮食对痤疮及皮肤表面甘油三酯脂肪酸组成的影响。
31名男性痤疮患者（年龄15 - 25岁）作为一项为期12周的平行设计饮食干预试验的一部分，完成了皮脂采样测试。实验性治疗采用低血糖负荷饮食，其中25%的能量来自蛋白质，45%来自低血糖指数碳水化合物。相比之下，对照情况强调高碳水化合物食物，未提及血糖指数。每月就诊时评估痤疮皮损数量。在基线和12周时，使用脂质吸收带评估毛囊皮脂流出量和皮肤表面甘油三酯的组成。
12周时，与对照组相比，接受实验饮食的受试者皮肤表面甘油三酯的饱和脂肪酸与单不饱和脂肪酸之比增加[5.3±2.0%（平均值±标准误）对 - 2.7±1.7%，P = 0.007]。饱和/单不饱和比的增加与痤疮皮损数量相关（r = - 0.39，P = 0.03）。毛囊皮脂流出量增加也与皮脂中不饱和脂肪酸比例增加相关（r = 0.49，P = 0.006）。
这表明去饱和酶在皮脂腺脂质生成和痤疮临床表现中可能发挥作用。然而，需要进一步研究来阐明饮食在皮脂腺生理学中的潜在作用。
