纺锤体定位：与肌动蛋白流背道而驰。
Spindle positioning: going against the actin flow.
机构信息
Collège de France, Center for Interdisciplinary Research in Biology, UMR-CNRS7241/INSERM-U1050, 11 place Marcelin Berthelot, 75005 Paris, France.
出版信息
Nat Cell Biol. 2011 Oct 3;13(10):1183-5. doi: 10.1038/ncb2352.
DOI:10.1038/ncb2352
PMID:21968992
Abstract
Successful completion of meiosis in vertebrate oocytes requires the localization and maintenance of the meiotic spindle at the cell cortex. Arp2/3-nucleated actin filaments are now shown to flow away from the cortex overlying the spindle, resulting in cytoplasmic streaming, which maintains the spindle in its asymmetric position.
摘要
脊椎动物卵母细胞减数分裂的成功完成需要将减数分裂纺锤体定位和维持在细胞皮层处。现在已经表明，由 Arp2/3 引发的肌动蛋白丝从覆盖纺锤体的皮层处流走，导致细胞质流动，从而将纺锤体保持在不对称位置。
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