Bolli Elisabetta, Quaglino Elena, Arigoni Maddalena, Lollini Pier-Luigi, Calogero Raffaele, Forni Guido, Cavallo Federica
Am J Cancer Res. 2011;1(2):255-264. Epub 2010 Dec 20.
Vaccines are one of the main arms of preventive medicine. Recently a large series of experiments with cancer-prone genetically engineered mice have shown that preventive vaccines are also extremely efficacious inhibitors of the progression of carcinogenesis. Early vaccination affords significant and persistent protection, whereas its efficacy fades when neoplastic lesions become more advanced. Our current attempts to use combination strategies and technological advances to make vaccines effective in cancer prevention able to cure more advanced stages of cancer lesions are based on the temporary and systemic T(reg) removal, the preparation of new bimodular plasmids for DNA vaccination, and the search for fresh target oncoantigens.
疫苗是预防医学的主要手段之一。最近,对易患癌症的基因工程小鼠进行的一系列大型实验表明,预防性疫苗也是致癌作用进展的极其有效的抑制剂。早期接种疫苗可提供显著且持久的保护,而当肿瘤性病变变得更严重时,其效果会减弱。我们目前尝试使用联合策略和技术进步,以使预防癌症有效的疫苗能够治愈更晚期的癌症病变,这些尝试基于临时和全身性去除调节性T细胞(T(reg))、制备用于DNA疫苗接种的新型双模块质粒以及寻找新的靶向癌抗原。