Kim S H, Hong J Y, Suk E H, Jeong S M, Park P H
Department of Anaesthesiology and Pain Medicine, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
Anaesth Intensive Care. 2011 Sep;39(5):899-903. doi: 10.1177/0310057X1103900540.
The purpose of this study was to determine the optimum bolus dose of propofol required to provide excellent conditions for tracheal intubation following inhalational induction of anaesthesia using 5% sevoflurane without neuromuscular blockade. Twenty-eight children, aged three to seven years, requiring anaesthesia for short duration surgery were recruited. Two minutes after beginning the inhalational induction with 5% sevoflurane and 60% nitrous oxide, a predetermined dose of propofol was injected over 10 seconds. Propofol dose was determined using the Dixon's up-and-down method, starting from 3 mg/kg (0.5 mg/kg as a step size). Laryngoscopy was performed 50 seconds after propofol injection. The optimum dose of propofol required for excellent intubating conditions was 1.39 +/- 0.37 mg/kg in 50% of children during inhalation induction using 5% sevoflurane and 60% nitrous oxide in the absence of neuromuscular blocking agents. From probit analysis, the 95% effective dose of propofol was 2.33 mg/kg (95% confidence interval 1.78 to 6.21 mg/kg).
本研究的目的是确定在使用5%七氟醚进行吸入诱导麻醉且无神经肌肉阻滞的情况下，为气管插管提供良好条件所需的丙泊酚最佳推注剂量。招募了28名年龄在3至7岁、需要进行短时间手术麻醉的儿童。在用5%七氟醚和60%氧化亚氮开始吸入诱导两分钟后，在10秒内注射预定剂量的丙泊酚。丙泊酚剂量采用Dixon上下法确定，起始剂量为3mg/kg（步长为0.5mg/kg）。在注射丙泊酚50秒后进行喉镜检查。在使用5%七氟醚和60%氧化亚氮进行吸入诱导且无神经肌肉阻滞剂的情况下，50%的儿童实现良好插管条件所需的丙泊酚最佳剂量为1.39±0.37mg/kg。通过概率分析，丙泊酚的95%有效剂量为2.33mg/kg（95%置信区间为1.78至6.21mg/kg）。
