Damadian Raymond V, Chu David
FONAR Corporation, 110 Marcus Drive, Melville, NY 11747, USA.
Physiol Chem Phys Med NMR. 2011;41:1-17.
UPRIGHT Multi-Position MR scanning has uncovered a key set of new observations regarding Multiple Sclerosis (MS), which observations are likely to provide a new understanding of the origin of MS. The new findings may also lead to new forms of treatment for MS. The UPRIGHT MRI has demonstrated pronounced anatomic pathology of the cervical spine in five of the MS patients studied and definitive cervical pathology in the other three. The pathology was the result of prior head and neck trauma. All eight MS patients entered the study on a first come first serve basis without priority, and all but one were found to have a history of serious prior cervical trauma which resulted in significant cervical pathology. The cervical pathology was visualized by UPRIGHT MRI. Upright cerebrospinal fluid (CSF) cinematography and quantitative measurements of CSF velocity, CSF flow and CSF pressure gradients in the upright patient revealed that significant obstructions to CSF flow were present in all MS patients. The obstructions are believed to be responsible for CSF "leakages" of CSF from the ventricles into the surrounding brain parenchyma which "leakages" can be the source of the MS lesions in the brain that give rise to MS symptomatology. The CSF flow obstructions are believed to result in increases in intracranial pressure (ICP) that generate "leakages" of the CSF into the surrounding brain parenchyma. In all but one MS patient, anatomic pathologies were found to be more severe in the upright position than in the recumbent position. Similarly, CSF flow abnormalities were found to be more severe in the upright position than in the recumbent position in all but one MS patient. Images of the MS patient anatomic pathologies and CSF flow abnormalities are provided with comparison images from normal examinees in Figures 1-15.
直立多体位磁共振扫描揭示了一组关于多发性硬化症（MS）的重要新观察结果，这些观察结果可能会为MS的起源提供新的理解。新发现也可能会带来MS的新治疗形式。直立式磁共振成像（MRI）在研究的5例MS患者中显示出颈椎明显的解剖病理学改变，在另外3例中显示出明确的颈椎病变。这种病变是先前头部和颈部创伤的结果。所有8例MS患者均按先来先服务的原则进入研究，无优先级，除1例患者外，其余患者均有严重的先前颈椎创伤史，导致明显的颈椎病变。颈椎病变通过直立式MRI可视化。直立位脑脊液（CSF）电影成像以及对直立位患者CSF速度、CSF流量和CSF压力梯度的定量测量显示，所有MS患者均存在明显的CSF流动梗阻。这些梗阻被认为是导致CSF从脑室“渗漏”到周围脑实质的原因，这种“渗漏”可能是大脑中MS病变的来源，从而引发MS症状。CSF流动梗阻被认为会导致颅内压（ICP）升高，从而使CSF“渗漏”到周围脑实质中。除1例MS患者外，在所有患者中，解剖病理学改变在直立位比卧位更严重。同样，除1例MS患者外，在所有患者中，CSF流动异常在直立位比卧位更严重。图1-15中提供了MS患者解剖病理学改变和CSF流动异常的图像以及正常受试者的对比图像。
