Caterson I D
Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
Drugs. 1990;39 Suppl 3:20-32. doi: 10.2165/00003495-199000393-00004.
Obesity is a major health and social problem worldwide for which no single satisfactory treatment exists. Because of the prevalence of the disease, numerous therapeutic strategies have been attempted--often unsuccessfully. Weight loss programmes based on dietary restriction of caloric intake and nutritional education, exercise, surgical (gastroplasty, gastric bypass) and procedural (gastric balloon, waist cord, jaw wiring, liposuction) intervention and pharmacotherapy (appetite suppressants, thermogenic agents, bulking agents) used alone or in combination, have produced weight loss in the short to medium term; however, weight is generally regained on discontinuation of treatment. Behaviour modification programmes appear to offer the highest success rate in the long term. Weight loss is not rapid, although losses of 10 to 15 kg have been achieved after 6 months, and this may be increased when behaviour modification therapy is combined with more aggressive treatments such as severe caloric restriction or jaw wiring. Behaviour modification is particularly beneficial in special patient groups such as the obese elderly, children or adolescents, and disabled patients. Thus, although it appears that each of the treatments developed for the management of obese patients has its place, the cornerstone of therapy for most patients remains a programme of dietary restriction, combined with exercise and behaviour modification.
肥胖是一个全球性的重大健康和社会问题,目前尚无一种令人满意的单一治疗方法。由于该疾病的普遍性,人们尝试了许多治疗策略,但往往未获成功。基于限制热量摄入的饮食限制和营养教育、运动、手术(胃成形术、胃旁路手术)以及程序干预(胃内气球、束腰带、颌间固定、抽脂)和药物治疗(食欲抑制剂、产热剂、填充剂)单独或联合使用的减肥计划,在短期至中期内实现了体重减轻;然而,治疗中断后体重通常会反弹。从长期来看,行为矫正计划似乎成功率最高。体重减轻并不迅速,尽管在6个月后已实现10至15千克的体重减轻,并且当行为矫正疗法与更积极的治疗方法(如严格的热量限制或颌间固定)相结合时,体重减轻可能会增加。行为矫正对特殊患者群体,如肥胖的老年人、儿童或青少年以及残疾患者特别有益。因此,尽管为肥胖患者开发的每种治疗方法似乎都有其用武之地,但大多数患者治疗的基石仍然是饮食限制计划,并结合运动和行为矫正。