UO Ortopedia e Traumatologia, AO Bolognini - Seriate (BG), and Ospedale SS Capitanio e Gerosa, Lovere (BG), Italy.
Aging Clin Exp Res. 2011 Apr;23(2 Suppl):22-4.
Osteoporosis is a mechanical incompetence of bone which finally leads to fracture. The occurrence of a fracture for a minor trauma is the definitive evidence of bone fragility and an indication of an higher probability for other fractures. Fracture at any site is a strong risk factor for a subsequent fracture, therefore any patient with a prevalent fracture is an ideal candidate for treatment due to the high risk for recurrence and to a favourable cost-benefit ratio. Most of the available pharmacological agents approved for osteoporosis treatment are effective in reducing fracture risk in this class of patients. Unfortunately, poor compliance is very common in patients treated for osteoporosis and this leads to reduced benefits and ineffectual costs. Dose regimen simplification is neither the only nor the most important solution to improve compliance, and a multifaceted strategy targeting cognitive, behavioural and emotional factors should be employed.
骨质疏松症是一种骨骼机械功能障碍，最终导致骨折。轻微创伤后发生骨折是骨骼脆弱的明确证据，也是发生其他骨折的更高可能性的指标。任何部位的骨折都是随后骨折的强烈危险因素，因此，任何患有常见骨折的患者都是治疗的理想人选，因为复发风险高，且具有良好的成本效益比。大多数已批准用于骨质疏松症治疗的药物在这类患者中可有效降低骨折风险。不幸的是，骨质疏松症治疗患者的依从性很差，这导致获益降低和无效的成本。简化剂量方案不是提高依从性的唯一方法，也不是最重要的方法，应采用针对认知、行为和情感因素的多方面策略。
