Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Nat Rev Mol Cell Biol. 2011 Oct 5;12(11):695-708. doi: 10.1038/nrm3207.
In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to the nucleus through LINC (links the nucleoskeleton and cytoskeleton) complexes that span the nuclear envelope and in turn anchor to networks of filaments in the nucleus. The metazoan nucleoskeleton includes nuclear pore-linked filaments, A-type and B-type lamin intermediate filaments, nuclear mitotic apparatus (NuMA) networks, spectrins, titin, 'unconventional' polymers of actin and at least ten different myosin and kinesin motors. These elements constitute a poorly understood 'network of networks' that dynamically reorganizes during mitosis and is responsible for genome organization and integrity.
在细胞质中，肌动蛋白聚合物、中间丝和微管可以与细胞表面黏附物结合，并相互连接形成复杂的网络。这个细胞骨架通过连接核骨架和细胞质的 LINC（link the nucleoskeleton and cytoskeleton）复合物锚定在核上，这些复合物跨越核膜，并反过来与核内的纤维网络连接。后生动物核骨架包括核孔连接的纤维、A型和 B 型核纤层中间丝、核有丝分裂装置（NuMA）网络、 spectrins、titin、“非常规”肌动蛋白聚合物以及至少十种不同的肌球蛋白和驱动蛋白马达。这些元件构成了一个尚未被充分了解的“网络的网络”，在有丝分裂过程中动态重组，并负责基因组的组织和完整性。
