Graduate School of Biology-Oriented Science and Technology, Kindai University, 930 Nishimitani, Kinokawa-shi, Wakayama 649-6493, Japan.
Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Aramaki Aza-Aoba 468-1, Aoba-ku, Sendai 980-0845, Japan.
J Biochem. 2021 Apr 18;169(3):237-241. doi: 10.1093/jb/mvab006.
The eukaryotic nucleus shows organized structures of chromosomes, transcriptional components and their associated proteins. It has been believed that such a dense nuclear environment prevents the formation of a cytoskeleton-like network of protein filaments. However, accumulating evidence suggests that the cell nucleus also possesses structural filamentous components to support nuclear organization and compartments, which are referred to as nucleoskeleton proteins. Nucleoskeleton proteins including lamins and actin influence nuclear dynamics including transcriptional regulation, chromatin organization and DNA damage responses. Furthermore, these nucleoskeleton proteins play a pivotal role in cellular differentiation and animal development. In this commentary, we discuss how nucleoskeleton-based regulatory mechanisms orchestrate nuclear dynamics.
真核细胞核显示出染色体、转录成分及其相关蛋白的有组织结构。人们一直认为，如此密集的核环境会阻止形成类似于细胞骨架的蛋白质丝网络。然而，越来越多的证据表明，细胞核还具有结构丝状成分来支持核组织和隔室，这些成分被称为核骨架蛋白。核骨架蛋白包括核纤层蛋白和肌动蛋白，它们影响核动态，包括转录调控、染色质组织和 DNA 损伤反应。此外，这些核骨架蛋白在细胞分化和动物发育中起着关键作用。在这篇评论中，我们讨论了基于核骨架的调节机制如何协调核动态。
