Spector A
Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Exp Eye Res. 1990 Jun;50(6):689-94. doi: 10.1016/0014-4835(90)90115-b.
A review of some of Dr Kinoshita's contributions to our understanding of lens protein and glutathione biochemistry is presented. Particular emphasis is placed on Dr Kinoshita's work involved with the relationship of carbohydrate metabolism and the maintenance of reduced glutathione, the question of the biological function of glutathione in the lens, the effect of oxidative stress provided by diamide and azoester on glutathione, membrane pump function and protein and also ascorbate and H2O2 effects on Na+, K(+)-ATPase. The importance of oxidative stress was recognized early by Dr Kinoshita and he has continued to make significant contributions in this area as illustrated by his work with Dr Zigler on posterior subcapsular cataracts and with Drs Garland and Zigler on mixed function oxidation. It is concluded that Dr Kinoshita's overall contributions in the areas mentioned above have been broad and of considerable importance.
本文回顾了木下博士在我们对晶状体蛋白和谷胱甘肽生物化学理解方面的一些贡献。特别强调了木下博士在碳水化合物代谢与还原型谷胱甘肽维持之间的关系、谷胱甘肽在晶状体中的生物学功能问题、二酰胺和偶氮酯提供的氧化应激对谷胱甘肽、膜泵功能和蛋白质的影响以及抗坏血酸和过氧化氢对Na +，K（+）-ATP酶的影响等方面的工作。木下博士很早就认识到氧化应激的重要性，并且他在这一领域继续做出了重大贡献，正如他与齐格勒博士关于后囊下白内障的合作以及与加兰博士和齐格勒博士关于混合功能氧化的合作所表明的那样。结论是，木下博士在上述领域的总体贡献广泛且具有相当重要的意义。
