谷胱甘肽与眼晶状体蛋白γ-晶状体蛋白的反应。
The reaction of glutathione with the eye-lens protein gamma-crystallin.
作者信息
Slingsby C, Miller L
出版信息
Biochem J. 1985 Aug 15;230(1):143-50. doi: 10.1042/bj2300143.
Abstract
Lens cells contain high concentrations of thiol-rich proteins, gamma-crystallins and reduced glutathione. Solutions of bovine gamma-crystallin react avidly with either reduced or oxidized glutathione to form protein-glutathione mixed disulphides. A method of purification of a gamma-II crystallin-glutathione adduct containing two mixed disulphide groups is described.
摘要
晶状体细胞含有高浓度的富含硫醇的蛋白质、γ-晶状体蛋白和还原型谷胱甘肽。牛γ-晶状体蛋白溶液能与还原型或氧化型谷胱甘肽迅速反应，形成蛋白质-谷胱甘肽混合二硫化物。本文描述了一种纯化含有两个混合二硫键的γ-II晶状体蛋白-谷胱甘肽加合物的方法。
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