Rathbun W B, Sethna S S, Skelnik D L, Bistner S I
Exp Eye Res. 1983 Jun;36(6):845-58. doi: 10.1016/0014-4835(83)90038-6.
Several biochemical parameters were examined in clear dog and rabbit lenses as functions of age, and in posterior subcapsular cataracts in the Alaskan malamute. Tabulated data include soluble protein, reduced sulfhydryl content of soluble protein, reduced glutathione, water, and activity of five enzymes of glutathione metabolism. The enzymes include the glutathione biosynthesis system consisting of gamma-glutamylcysteine synthetase and glutathione synthetase, as well as glutathione peroxidase, glutathione reductase and glutathione-S-transferase. Each enzyme, acting last in a sequential reaction of either two or three reactions, was in excess activity over the preceding enzyme(s) in every case but one. In the exception, the ratio of glutathione reductase to glutathione peroxidase activity was about 1:600 and 1:155 in the dog and rabbit lens, respectively.
研究了透明犬和兔晶状体中若干生化参数随年龄的变化情况，以及阿拉斯加雪橇犬后囊下白内障中的这些参数。列表数据包括可溶性蛋白质、可溶性蛋白质的还原巯基含量、还原型谷胱甘肽、水以及谷胱甘肽代谢的五种酶的活性。这些酶包括由γ-谷氨酰半胱氨酸合成酶和谷胱甘肽合成酶组成的谷胱甘肽生物合成系统，以及谷胱甘肽过氧化物酶、谷胱甘肽还原酶和谷胱甘肽-S-转移酶。在每一种情况下，除了一种情况外，每种酶在两个或三个连续反应中最后起作用，其活性都超过前一种酶。在例外情况下，犬和兔晶状体中谷胱甘肽还原酶与谷胱甘肽过氧化物酶活性的比率分别约为1:600和1:155。
