Inserm, U1003, Laboratoire de Physiologie Cellulaire, Equipe labelisée par la Ligue contre le cancer, Villeneuve d'Ascq, F-59650 France.
Nat Rev Urol. 2011 Oct 4;8(11):617-30. doi: 10.1038/nrurol.2011.142.
The members of transient receptor potential (TRP) superfamily of cationic ion channels represent universal sensors, which convert multiple exogenous and endogenous chemical and physical stimuli into electrical and functional cellular responses. TRPs are widely distributed in many different tissues, and expression of numerous TRP types has been reported in lower urinary tract (LUT) tissues, neuronal fibers innervating the bladder and urethra, and epithelial and muscular layers of the bladder and urethral walls, where they are mainly involved in nociception and mechanosensory transduction. As such, they represent attractive targets for treating LUT disorders. Although information on the functional significance of many of the TRP proteins in the LUT remains very limited, compelling evidence has accumulated for a pivotal role of TRPV1, TRPV2, TRPV4, TRPM8, and TRPA1 in normal and pathological LUT function, mainly as sensors of stretch and chemical irritation. Further studies into these and other TRPs in the LUT will facilitate the development of improved therapeutic strategies to target these channels in LUT disorders.
瞬时受体电位 (TRP) 阳离子通道超家族的成员是通用传感器，可将多种外源性和内源性化学和物理刺激转化为电和功能细胞反应。TRPs 广泛分布于许多不同的组织中，并且已经在下尿路 (LUT) 组织、支配膀胱和尿道的神经元纤维以及膀胱和尿道壁的上皮和肌肉层中报告了许多 TRP 类型的表达，它们主要参与痛觉和机械感觉转导。因此，它们是治疗 LUT 疾病的有吸引力的靶点。尽管有关 LUT 中许多 TRP 蛋白的功能意义的信息仍然非常有限，但已经积累了大量证据表明 TRPV1、TRPV2、TRPV4、TRPM8 和 TRPA1 在正常和病理 LUT 功能中起着关键作用，主要作为伸展和化学刺激的传感器。进一步研究 LUT 中的这些和其他 TRPs 将有助于制定改善的治疗策略，以针对 LUT 疾病中的这些通道。
