Yao Kaifang, Dou Baomin, Zhang Yue, Chen Zhihan, Li Yanwei, Fan Zezhi, Ma Yajing, Du Simin, Wang Jiangshan, Xu Zhifang, Liu Yangyang, Lin Xiaowei, Wang Shenjun, Guo Yi
Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Physiol. 2023 Feb 16;14:1093925. doi: 10.3389/fphys.2023.1093925. eCollection 2023.
Recently, increasing numbers of studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1) can be used as a potential target for the treatment of inflammatory diseases. TRPA1 is expressed in both neuronal and non-neuronal cells and is involved in diverse physiological activities, such as stabilizing of cell membrane potential, maintaining cellular humoral balance, and regulating intercellular signal transduction. TRPA1 is a multi-modal cell membrane receptor that can sense different stimuli, and generate action potential signals after activation osmotic pressure, temperature, and inflammatory factors. In this study, we introduced the latest research progress on TRPA1 in inflammatory diseases from three different aspects. First, the inflammatory factors released after inflammation interacts with TRPA1 to promote inflammatory response; second, TRPA1 regulates the function of immune cells such as macrophages and T cells, In addition, it has anti-inflammatory and antioxidant effects in some inflammatory diseases. Third, we have summarized the application of antagonists and agonists targeting TRPA1 in the treatment of some inflammatory diseases.
最近，越来越多的研究表明，瞬时受体电位锚蛋白1（TRPA1）可作为治疗炎症性疾病的潜在靶点。TRPA1在神经元细胞和非神经元细胞中均有表达，并参与多种生理活动，如稳定细胞膜电位、维持细胞体液平衡以及调节细胞间信号转导。TRPA1是一种多模态细胞膜受体，能够感知不同刺激，并在受到渗透压、温度和炎症因子等激活后产生动作电位信号。在本研究中，我们从三个不同方面介绍了TRPA1在炎症性疾病中的最新研究进展。第一，炎症发生后释放的炎症因子与TRPA1相互作用以促进炎症反应；第二，TRPA1调节巨噬细胞和T细胞等免疫细胞的功能，此外，它在某些炎症性疾病中具有抗炎和抗氧化作用。第三，我们总结了靶向TRPA1的拮抗剂和激动剂在治疗某些炎症性疾病中的应用。
