认知训练可改变轻度认知障碍患者的海马功能：一项初步研究。
Cognitive training changes hippocampal function in mild cognitive impairment: a pilot study.
机构信息
Department of Psychiatry, Stanford University, Stanford, CA, USA.
出版信息
J Alzheimers Dis. 2011;26 Suppl 3(Suppl 3):349-57. doi: 10.3233/JAD-2011-0009.
Abstract
A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.
摘要
一项随机先导实验研究了轻度认知障碍（MCI）患者对认知训练反应的神经基础。参与者进行了先前证明可以改善言语记忆的练习，而积极对照组则进行了其他计算机活动。在为期两个月的训练计划前后进行了听觉言语 fMRI 任务。与对照组（所有 6 名参与者的记忆力下降）相比，实验组的言语记忆评分显著提高，左海马激活显著增加（6 名参与者中有 5 名的记忆力提高）。结果表明，MCI 患者的海马体可能具有足够的神经可塑性，可以从认知训练中受益。
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