Tsiakiri Anna, Plakias Spyridon, Vlotinou Pinelopi, Athanasouli Paraskevi, Terzoudi Aikaterini, Kyriazidou Sotiria, Serdari Aspasia, Karakitsiou Georgia, Megari Kalliopi, Aggelousis Nikolaos, Vadikolias Konstantinos, Christidi Foteini
Department of Neurology, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece.
Eur J Investig Health Psychol Educ. 2025 Mar 12;15(3):34. doi: 10.3390/ejihpe15030034.
Minor neurocognitive disorders (NCDs) represent a transitional phase between normal cognitive aging and dementia, highlighting the importance of early interventions. This study assessed the efficacy of a structured 6-month computerized cognitive training (CCT) program in stabilizing cognitive decline among older adults with minor NCDs. One hundred participants were randomly assigned to an intervention group or a non-intervention group. The intervention group underwent weekly, personalized CCT sessions using the MeMo program, which targeted memory, attention, and adaptability. Cognitive performance was measured at baseline and after six months using the Cambridge Cognitive Examination (CAMCOG). Statistical analysis showed significant cognitive decline in the non-intervention group in orientation ( = 0.032), language expression ( = 0.008), praxis ( = 0.008), and memory ( = 0.01). In contrast, the intervention group showed no significant changes, except for a minor decline in perception ( = 0.003). These results suggest that CCT may help delay cognitive deterioration in minor NCDs. However, while cognitive decline was stabilized, no significant improvement was observed. Further research is recommended to investigate the long-term benefits and the transferability of cognitive gains. The findings support the use of CCT as a non-pharmacological health promotion strategy for enhancing cognitive resilience in aging populations. The novelty of this research lies in its focus on adaptive CCT as a non-pharmacological intervention, highlighting the potential role of neuroplasticity in delaying cognitive decline and offering new insights into personalized cognitive health strategies for aging populations.
轻度神经认知障碍（NCDs）代表了正常认知衰老与痴呆之间的过渡阶段，凸显了早期干预的重要性。本研究评估了一项为期6个月的结构化计算机化认知训练（CCT）计划在稳定轻度NCDs老年人认知衰退方面的效果。100名参与者被随机分配到干预组或非干预组。干预组使用MeMo程序每周进行个性化的CCT训练，该训练针对记忆、注意力和适应性。在基线和6个月后使用剑桥认知检查（CAMCOG）测量认知表现。统计分析显示，非干预组在定向（P = 0.032）、语言表达（P = 0.008）、实践（P = 0.008）和记忆（P = 0.01）方面有显著的认知衰退。相比之下，干预组除了在感知方面有轻微下降（P = 0.003）外，没有显著变化。这些结果表明，CCT可能有助于延缓轻度NCDs患者的认知恶化。然而，虽然认知衰退得到了稳定，但未观察到显著改善。建议进一步研究以调查长期益处和认知收益的可转移性。这些发现支持将CCT作为一种非药物健康促进策略用于增强老年人群的认知恢复力。本研究的新颖之处在于其关注适应性CCT作为一种非药物干预措施，突出了神经可塑性在延缓认知衰退中的潜在作用，并为老年人群的个性化认知健康策略提供了新的见解。
