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本文引用的文献

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Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders.心境障碍谷氨酸相关异常的磁共振波谱研究。
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mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.mTOR 依赖性突触形成是 NMDA 拮抗剂快速抗抑郁作用的基础。
Science. 2010 Aug 20;329(5994):959-64. doi: 10.1126/science.1190287.
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A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.一项关于 N-甲基-D-天冬氨酸拮抗剂治疗难治性双相抑郁的随机附加试验。
Arch Gen Psychiatry. 2010 Aug;67(8):793-802. doi: 10.1001/archgenpsychiatry.2010.90.
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Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder.在治疗抵抗性重度抑郁症患者中，单次输注 N-甲基-D-天冬氨酸拮抗剂后，自杀意念迅速缓解。
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Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine.在前扣带皮层去同步化和与杏仁核的功能连接在工作记忆任务期间预测对氯胺酮的快速抗抑郁反应。
Neuropsychopharmacology. 2010 Jun;35(7):1415-22. doi: 10.1038/npp.2010.24. Epub 2010 Mar 10.
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Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole.锂剂治疗双相抑郁后谷氨酸能神经传递的快速增强。
Neuropsychopharmacology. 2010 Feb;35(3):834-46. doi: 10.1038/npp.2009.191. Epub 2009 Dec 2.
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Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment.GRIA4、HTR2A 和 FKBP5 中的多态性在预测抗抑郁治疗的缓解方面存在交互作用。
Neuropsychopharmacology. 2010 Feb;35(3):727-40. doi: 10.1038/npp.2009.180. Epub 2009 Nov 18.
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Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression.重复静脉注射氯胺酮治疗难治性抑郁症的安全性和有效性。
Biol Psychiatry. 2010 Jan 15;67(2):139-45. doi: 10.1016/j.biopsych.2009.08.038.
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Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist.脑源性神经营养因子与 N-甲基-D-天冬氨酸拮抗剂的早期抗抑郁反应。
J Clin Psychiatry. 2009 Dec;70(12):1662-6. doi: 10.4088/JCP.08m04659. Epub 2009 Sep 8.
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Memantine efficacy and safety in patients with acute mania associated with bipolar I disorder: a pilot evaluation.美金刚对伴有双相I型障碍的急性躁狂症患者的疗效及安全性：一项初步评估。
Clin Neuropharmacol. 2009 Jul-Aug;32(4):199-204. doi: 10.1097/WNF.0b013e318184fae2.

新型谷氨酸能药物治疗重性抑郁障碍和双相障碍。

Novel glutamatergic agents for major depressive disorder and bipolar disorder.

机构信息

LIM-27, Institute and Department of Psychiatry, University of Sao Paulo Medical School, USP, Sao Paulo, Brazil.

出版信息

Pharmacol Biochem Behav. 2012 Feb;100(4):678-87. doi: 10.1016/j.pbb.2011.09.010. Epub 2011 Sep 25.

DOI:10.1016/j.pbb.2011.09.010
PMID:21971560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3253881/
Abstract

Mood disorders such as major depressive disorder (MDD) and bipolar disorder (BPD) are common, chronic, recurrent mental illnesses that affect the lives and functioning of millions of individuals worldwide. Growing evidence suggests that the glutamatergic system is central to the neurobiology and treatment of these disorders. Here, we review data supporting the involvement of the glutamatergic system in the pathophysiology of mood disorders as well as the efficacy of glutamatergic agents as novel therapeutics.

摘要

心境障碍，如重度抑郁症（MDD）和双相情感障碍（BPD），是常见的、慢性的、复发性精神疾病，影响着全球数以百万计的个体的生活和功能。越来越多的证据表明，谷氨酸能系统是这些疾病的神经生物学和治疗的核心。在这里，我们回顾了支持谷氨酸能系统参与心境障碍病理生理学以及谷氨酸能药物作为新型治疗药物的疗效的数据。