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功能性运动障碍患者脑脊液中谷氨酸的变化

Cerebrospinal fluid glutamate changes in functional movement disorders.

作者信息

Demartini Benedetta, Invernizzi Roberto William, Campiglio Laura, Bocci Tommaso, D'Arrigo Andrea, Arighi Andrea, Sciacca Francesca, Galimberti Daniela, Scarpini Elio, Gambini Orsola, Priori Alberto

机构信息

Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.

Unità di Psichiatria II, A.O. San Paolo, ASST Santi Paolo e Carlo, Milano, Italy.

出版信息

NPJ Parkinsons Dis. 2020 Dec 4;6(1):37. doi: 10.1038/s41531-020-00140-z.

DOI:10.1038/s41531-020-00140-z
PMID:33298941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7718900/
Abstract

The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.

摘要

本研究的目的是使用高效液相色谱系统评估功能性运动障碍（FMD）患者样本和对照样本中特定氨基酸的脑脊液（CSF）浓度。FMD患者的脑脊液谷氨酸水平显著低于对照组。这一发现支持了FMD病理生理学中谷氨酸能功能障碍的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7718900/080169496d83/41531_2020_140_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7718900/080169496d83/41531_2020_140_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7718900/080169496d83/41531_2020_140_Fig1_HTML.jpg

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