Staten Island University Hospital, Staten Islan, NY 10305, USA.
Chron Respir Dis. 2011;8(4):233-5. doi: 10.1177/1479972311416381. Epub 2011 Oct 4.
Tracheal papillomatosis (TP) is a benign condition characterized by papillomatous growth of the bronchial epithelium that involves the trachea. This abnormal growth is a result of infection with human papilloma virus (HPV). Two subtypes of HPV were found in most cases of TP, HPV-6 and HPV-11. TP, presents in two forms, the juvenile onset (JO) or adult onset (AO). The clinical presentation is typically nonspecific and it ranges from mild symptoms like cough to life-threatening conditions like upper airway obstruction. Treatment depends on the location of the papillomas and age of the patient and the plan of therapy is usually made on an individual basis. Treatment can range from observation with symptomatic control to specific medical therapy and multiple surgeries in case of recurrence or progressively worsening disease. The recent invention of HPV vaccine is expected to be the first step in eradicating respiratory papillomatosis.
气管乳头状瘤病（TP）是一种良性疾病，其特征为支气管上皮的乳头状生长，累及气管。这种异常生长是由人乳头瘤病毒（HPV）感染引起的。大多数 TP 病例中发现有两种 HPV 亚型，HPV-6 和 HPV-11。TP 有两种形式，即青少年发病（JO）或成人发病（AO）。临床表现通常是非特异性的，从咳嗽等轻度症状到危及生命的上呼吸道阻塞等情况均有。治疗取决于乳头状瘤的位置和患者的年龄，治疗方案通常是个体化制定的。治疗方法可以从观察伴有症状控制，到特定的药物治疗以及多次手术，具体取决于复发或疾病逐渐恶化的情况。HPV 疫苗的最近发明有望成为根除呼吸道乳头状瘤病的第一步。
