Leuppi J D, Wildhaber J H, Spertini F, Helbling A
Innere Medizin, Universitätsspital Basel.
Praxis (Bern 1994). 2011 Oct 5;100(20):1225-34. doi: 10.1024/1661-8157/a000687.
Asthma and allergic rhinitis are chronic inflammatory airway diseases which often occur concomitantly. The objective of the LARA program was to identify the comorbidities and characteristics of asthma (A), intermittent or persistent rhinitis (IPR) and physician defined atopic dermatitis (AD) in 6- to 16-year old asthmatic Swiss children and adolescents. Overall, 126 general practitioners and paediatricians collected the data of 670 asthmatics. Approximately one third of the asthmatic children in Switzerland had well-controlled asthma. Almost two thirds of these asthmatics suffered from concomitant IPR. The latter presented with significantly less symptoms while the treatment rates with inhaled corticosteroids (approximately 90%) and leukotriene-receptorantagonists (approximately 50%) were comparable. However, there were almost twice as many passive smokers in the less well-controlled group. The prevalence of AD was similar in both groups. IPR and AD may play an important role as risk factors in the future development of asthma.
哮喘和过敏性鼻炎是常常同时发生的慢性气道炎症性疾病。LARA项目的目的是确定6至16岁瑞士哮喘儿童和青少年中哮喘(A)、间歇性或持续性鼻炎(IPR)以及医生定义的特应性皮炎(AD)的合并症和特征。总体而言,126名全科医生和儿科医生收集了670名哮喘患者的数据。瑞士约三分之一的哮喘儿童哮喘控制良好。这些哮喘患者中近三分之二患有合并的IPR。后者症状明显较少,而吸入性糖皮质激素(约90%)和白三烯受体拮抗剂(约50%)的治疗率相当。然而,控制较差的组中被动吸烟者几乎是另一组的两倍。两组中AD的患病率相似。IPR和AD可能作为危险因素在哮喘未来发展中起重要作用。